Category: Jacobs journal of cancer science and research

  • Metrics details. Current guidelines recommend that "overweight" and "obese" individuals lose weight through engaging in lifestyle modification involving diet, exercise and other behavior change. This approach reliably induces short term weight loss, but the majority of individuals are unable to maintain weight loss over the long term and do not achieve the putative benefits of improved morbidity and mortality.

    Concern has arisen that this weight focus is not only ineffective at producing thinner, healthier bodies, but may also have unintended consequences, contributing to food and body preoccupation, repeated cycles of weight loss and regain, distraction from other personal health goals and wider health determinants, reduced self-esteem, eating disorders, other health decrement, and weight stigmatization and discrimination.

    This concern has drawn increased attention to the ethical implications of recommending treatment that may be ineffective or damaging. A growing trans-disciplinary movement called Health at Every Size HAES challenges the value of promoting weight loss and dieting behavior and argues for a shift in focus to weight-neutral outcomes. Randomized controlled clinical trials indicate that a HAES approach is associated with statistically and clinically relevant improvements in physiological measures e.

    This paper evaluates the evidence and rationale that justifies shifting the health care paradigm from a conventional weight focus to HAES. Peer Review reports. Concern regarding "overweight" and "obesity" is reflected in a diverse range of policy measures aimed at helping individuals reduce their body mass index BMI 1.

    Concern has arisen that this weight focused paradigm is not only ineffective at producing thinner, healthier bodies, but also damaging, contributing to food and body preoccupation, repeated cycles of weight loss and regain, distraction from other personal health goals and wider health determinants, reduced self-esteem, eating disorders, other health decrement, and weight stigmatization and discrimination [ 6 — 8 ].

    As evidence-based competencies are more firmly embedded in health practitioner standards, attention has been given to the ethical implications of recommending treatment that may be ineffective or damaging [ 59 ].

    The primary intent of HAES is to support improved health behaviors for people of all sizes without using weight as a mediator; weight loss may or may not be a side effect.

    jacobs journal of cancer science and research

    An international professional organization, the Association for Size Diversity and Health, has developed, composed of individual members across a wide span of professions who are committed to HAES principles.

    Several clinical trials comparing HAES to conventional obesity treatment have been conducted. Some investigations were conducted before the name "Health at Every Size" came into common usage; these earlier studies typically used the terms "non-diet" or "intuitive eating" and included an explicit focus on size acceptance as opposed to weight loss or weight maintenance.

    A Pub Med search for "Health at Every Size" or "intuitive eating" or "non-diet" or "nondiet" revealed 57 publications. Randomized controlled trials RCTs were vetted from these publications, and additional RCTs were vetted from their references.

    Only studies with an explicit focus on size acceptance were included. Evidence from these six RCTs indicates that a HAES approach is associated with statistically and clinically relevant improvements in physiological measures e.

    jacobs journal of cancer science and research

    See Table 1. All studies indicate significant improvements in psychological and behavioral outcomes; improvements in self-esteem and eating behaviors were particularly noteworthy [ 11 — 1416171920 ]. Four studies additionally measured metabolic risk factors and three of these studies indicated significant improvement in at least some of these parameters, including blood pressure and blood lipids [ 111216171920 ].

    No studies found adverse changes in any variables. A seventh RCT reported at a conference also found significantly positive results [ 18 ], as did a non-randomized controlled study [ 21 ] and five studies conducted without a control [ 22 — 26 ].

    All of the controlled studies showed retention rates substantially higher than, or, in one instance, as high, as the control group, and all of the uncontrolled studies also showed high retention rates. Given the well-documented recidivism typical of weight loss programs [ 52728 ] and the potential harm that may arise[ 2930 ], this aspect is particularly noteworthy. Dieting and other weight loss behaviors are popular in the general population and widely encouraged in public health policy and health care practice as a solution for the "problem" of obesity.We have created a central resources hub for Health Professionals which hosts all of our CRUK resources and further materials to help with managing the pandemic.

    We are updating the information as guidance changes. There is also a page specifically for patients on our about cancer hub. Older age is the main risk factor for cancer. This largely reflects cell DNA damage accumulating over time.

    Damage can result from biological processes or from exposure to risk factors. This page covers other factors with the best evidence of an association with cancer risk; this list is not exhaustive. See our other pages for general information about cancer, or ways to reduce your risk. Lifetime risk for all cancers combined and cancers compared. Pancreatic cancer incidence statistics. How risk is calculated.

    Want to generate bespoke preventable cancers stats statements? Data is for UK, past and projected cancer incidence and mortality and all-cause mortality rates for those born inICD C The calculations used past and projected cancer incidence and mortality and all-cause mortality rates for those born in to project risk over the lifetime of those born in cohort method.

    Download our interactive statement generator. Find out more about the definitions and evidence for this data. Learn how attributable risk is calculated. Pancreatic cancer risk is 2. Pancreatic cancer risk is increased to a similar extent in people who smoke cigars only and people who smoke cigarettes only, a pooled analysis showed. Pancreatic cancer risk in those who quit smoking 20 years ago is similar to that of never-smokers, a pooled analysis showed.

    Pancreatic cancer risk is not associated with ever-use of smokeless tobacco overall, compared with never-use of any tobacco, a pooled analysis and systematic review have shown. UK portrait version shown here. Country versions, cancers caused by other risk factors, and landscape formats are available for free from our cancer risk publications.

    See IARC's classifications on the role of this risk factor. View our statistics on tobacco and cancer. View our health information on smoking and cancer. View our health information on obesity, weight and cancer. View our statistics on alcohol and cancer. Pancreatic cancer risk is higher in people with the following rare genetic conditions, compared with the general population:[ 3,4 ].

    These genetic syndromes explain a small proportion of familial pancreatic cancer. See more information on how inherited genes can be a cause of cancer. Pancreatic cancer risk is at least threefold higher in people with chronic pancreatitis versus those without, a meta-analysis showed.

    Residual confounding by smoking and alcohol use may explain some of the association.UB is the premier public research university in the Northeastern United States and the largest and most comprehensive campus in the campus SUNY system. The CAS offers a comprehensive range of degrees and programs through its 29 departments, 25 centers and institutes, two art galleries, and major theater and music performance venues.

    Among the top dental schools in the country, the School of Dental Medicine is known for the quality of its DDS and postgraduate programs, and its long history of leadership in oral biology research. UB's School of Management is recognized for its emphasis on real-world learning, community and economic impact, and the global perspective of its faculty, students and alumni. The school also has been ranked by Bloomberg Businessweek, Forbes and U.

    It houses one of the world's top graduate programs in pharmaceutical sciences, along with a professional PharmD program that ranks in the top 25 percent nationally. The UB School of Public Health and Health Professions is home to innovative research that uses a global perspective to examine critical health issues.

    They are designed for individuals pursuing careers in cancer research or in basic and translational biomedical research.

    Our Schools and Colleges. Department of Architecture. Department of Urban and Regional Planning. Jacobs School of Medicine and Biomedical Sciences.

    School of Pharmacy and Pharmaceutical Sciences. School of Public Health and Health Professions. Roswell Park graduate division website.

    PhD program in Cancer Sciences.Since aspartame was first approved inboth FDA scientists and independent scientists have raised concerns about possible health effects and shortcomings in the science submitted to the FDA by the manufacturer, G. Monsanto bought Searle in InUPI published a series of investigative articles by Gregory Gordon reporting on these concerns, including early studies linking aspartame to health problems, the poor quality of industry-funded research that led to its approval, and the revolving-door relationships between FDA officials and the food industry.

    See also. While many studies, some of them industry sponsored, have reported no problems with aspartame, dozens of independent studies conducted over decades have linked aspartame to a long list of health problems, including:. In the most comprehensive cancer research to date on aspartame, three lifespan studies conducted by the Cesare Maltoni Cancer Research Center of the Ramazzini Institute, provide consistent evidence of carcinogenicity in rodents exposed to the substance.

    Harvard researchers in reported a positive association between aspartame intake and increased risk of non-Hodgkin lymphoma and multiple myeloma in men, and for leukemia in men and women. On the basis of the evidence of the potential carcinogenic effects … a re-evaluation of the current position of international regulatory agencies must be considered an urgent matter of public health.

    Early studies on aspartame in the s found evidence of brain tumors in laboratory animals, but those studies were not followed up.

    Aspartame: Decades of Science Point to Serious Health Risks

    People drinking diet soda daily were almost three times as likely to develop stroke and dementia as those who consumed it weekly or less. The study describes three previously healthy adults who had grand mal seizures during periods when they were consuming high doses of aspartame. Aspartame has been linked to behavioral and cognitive problems including learning problems, headache, seizure, migraines, irritable moods, anxiety, depression, and insomnia, wrote the researchers of a study in Nutritional Neuroscience.

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    It appears that some people are particularly susceptible to headaches caused by aspartame and may want to limit their consumption.

    Several studies link aspartame to weight gain, increased appetite, diabetes, metabolic derangement and obesity-related diseases. Aspartame breaks down in part into phenylalanine, which interferes with the action of an enzyme intestinal alkaline phosphatase IAP previously shown to prevent metabolic syndrome a group of symptoms associated with type 2 diabetes and cardiovascular disease according to a study in Applied Physiology, Nutrition and Metabolism.

    In this study, mice receiving aspartame in their drinking water gained more weight and developed other symptoms of metabolic syndrome than animals fed similar diets lacking aspartame. In a study that followed 66, women over 14 years, both sugar-sweetened beverages and artificially sweetened beverages were associated with risk of Type 2 diabetes.

    Artificial sweeteners can induce glucose intolerance by altering the gut microbiota, according to a study in Nature. Artificially sweetened beverage consumption during pregnancy is linked to higher body mass index for babies, according to a study in JAMA Pediatrics.

    The National Heart, Lung, and Blood Institute Growth and Health Study followed girls for 10 years to examine prospective associations between consumption of caffeinated and noncaffeinated sugar- and artificially sweetened soft drinks and early menarche. These data suggest that long-term intake of soft drink or aspartame-induced hepatic damage may be mediated by the induction of hyperglycemia, lipid accumulation, and oxidative stress with the involvement of adipocytokines.

    From the start, G.

    Jacob Wilson, PhD -- Human Optimization: The Role of Ketogenic Dieting and Resistance Training

    Searle later Monsanto and the NutraSweet Company deployed aggressive PR tactics to market aspartame as a safe product. Burson Marsteller declines to discuss such matters. Recent reporting based on internal industry documents reveals how beverage companies such as Coca-Cola also pay third party messengers, including doctors and scientists, to promote their products and shift the blame when science ties their products to serious health problems.

    Pancreatic cancer risk

    PMID: Epub Jan Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. Low-calorie sweetener use and energy balance: Results from experimental studies in animals, and large-scale prospective studies in humans.

    Physiol Behav. Epub Apr Epub Dec As a result of the significant disruption that is being caused by the COVID pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times. Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time. Read more here.

    jacobs journal of cancer science and research

    Authors: Janine A. Kamphuis, Marijke Linschoten, Maarten J. Cramer, Pieter A. Doevendans, Folkert W. Asselbergs and Arco J. El Masry.

    PubMed Journals will be shut down

    Slingluff Jr and Elizabeth M. Authors: Anecita P. Fadol, Nicolas L. Palaskas, Michael S. Ewer and Anita Deswal. Authors: Claire C. Conley, Neha G. Goyal and Sherry-Ann Brown. Most recent articles RSS.

    jacobs journal of cancer science and research

    View all articles. Hochberg and Leon M. Authors: Anthony F. Yu and Lee W. Most accessed articles RSS. The society brings together cardio-oncologists from around the world with the aim of reducing cardiovascular disease in cancer patients and thereby saving patients' lives. For more information about this important work, please visit the ICOS website. The discount should be requested during the submission process.

    Steven E. His research interests focus on pharmacokinetics, pharmacodynamics, and clinical correlates of anticancer drugs cardiovascular toxicity.

    Visit the membership page to check if your institution is a member and learn how you could save on article-processing charges APCs. Learn more here.PubMed Journals helped people follow the latest biomedical literature by making it easier to find and follow journals, browse new articles, and included a Journal News Feed to track new arrivals news links, trending articles and important article updates.

    PubMed Journals was a successful experiment. Since Septembernearly 20, people followed 10, distinct journals. Each customer followed 3 journals on average. We appreciate your feedback over the years that made PubMed Journals a productive test of new ideas.

    What does this mean? I followed a link to an article and I get this page? How am I supposed to see the article?! The PubMed Journals site now redirects here, as that experiment is now over. You should be able to search and find articles on PubMed, as usual. Please email us at info ncbi. Does this mean that PubMed will no longer be publicly accessible? Surely not? What DOES it mean? Where is the headlined article?

    Will someone reply to this? I see similar questions, but no replies. This means that the PubMed Journals experimental site is no longer available.

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    Terrible news. I have referred so many of my students to this to help them as teachers. I guess another budget cut in the wrong place. Yes terribly unfair and in-adapted to the actual situation, it should have been more opened instead, incredible and so disappointed!

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    I feel like a part of me has been robbed, lost and taken from me with no regard! Say this isnt so!! PubMed offered the ability to maximize easy access to current research from the laboratories around the world from your home computer!!

    Any new ideas could be explored for possibility of validity. The site leveled the playing field for a scientist in city college without a lab versus labs in Harvard or Yale.

    Innovation without funding versus current accepted funded theories have research results at their finger tips, free of pre-conceived prejudice. The site provides the most fertile basis and potential for new discoveries without bias.

    Continue to provide a portal for unbiased access to immediate unfolding research to foster science based creativity. Sometimes that requires retiring tools or other resources. Thanks for sharing this valuable and authentic information with us. Please share something more knowledgeable like that.In this article, we will look at the next section in IELTS Listening test i. In this section, almost all the times, you find sentenceIELTS Listening module consists of 4 sections viz.

    Section 1, Section 2, Section 3 and Section 4. Out of all these sections, Section 3 is the part where you listen to audio conversation of up to 4 people. This is perhapsSection 2 is one of the easy parts in IELTS listening exam because in this section, you hear an audio which is a monologue where only one speaker is there to talk about every day social situation.

    IELTS Listening Section 2 generally consists ofSo,In this article, we are putting up model answers for the Recent Exam IELTS Speaking task 3 question. The examiner will take your face to face interview. The examiner will lead you through the three parts of the test: An introduction A speak up where the candidate speaksIn this article we are going to focus on improving our speaking skills for IELTS Speaking Exam.

    We will analyse the speech of a trainer, the audio of which is attached in this article.

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    The IELTS Speaking Exam has threeIn this article we are going to focus on improving our speaking skills for IELTS Speaking Exam. The IELTS Speaking Exam has threeLet us try to find out an IELTS speaking cue card topic that recently appeared in the exam. Please say Where do you go.

    HowA book on Speaking. Not only because learning speaking through a book may be difficult but also because the material of a good speaking book can only be curated by a specialist in that field. TheRecent Exam Question- Speaking Prompt (16th June 2017) Exam Question:-Speaking prompt Describe a situation when a known person solved a problem sensibly.

    What was the problem and how he solved it. Do you thinkRecent exam questions for IELTS Speaking. Speaking Cue Card Question Describe an important decision that you made in your life : You should say : What the decision was When did you took it What was the result of theRecent IELTS Speaking Cue Card Question- June 2017.

    She wanted to achieve good band score so that she could apply for immigration in her intended country,Student Background Shubha Kapoor (imaginary name) is a homemaker from the capital city, New Delhi.

    She had been on leave from work for a while with the desire to apply for immigration to Canada. This IELTS case study is about thisStudent Background This inspiring IELTS case study is about Anand Kishore (imaginary name), software engineer from Indore with the desire to apply for immigration to Canada, who wanted to meet the cut off score in order to get himself registeredStudent Background Pooja Shetty (imaginary name) was a student studying in her final year of graduation who wanted to pursue her dream of higher education studies outside India.

    She wanted to score 7. He had a dream of immigrating to Australia with his family for which he needed to meet the minimum criterion. He had appeared in IELTS examStudent Background Balachandran (imaginary name, not disclosed for privacy) is an experienced mechanical engineer from Andhra Pradesh.

    He badly needed to boost up his IELTS score from 5. He desperately needed 7 BandIELTS test stands for- International English Language Testing System. There are two versions of IELTS to choose from: IELTS Academic IELTS General Training EveryoneThere is no way you can assess your own Speaking task and Writing task.

    IELTS is a tough exam and worrying about your Writing task and Speaking task, feeling insecure or looking for a way to estimate your score before takingWhy do you need an IELTS Diagnostic Test. IELTS is a reasonably challenging exam, knowing where you stand can do a world of difference to your preparation.

    This IELTS Diagnostic Test can help you in the following ways Give youCoherence and Cohesion in Writing and speaking task have the highest weight age in IELTS exam. While this is probably taken lightly by the candidates and that is where they score a low band. You have to avoid the repeatedEvery candidate feels that the IELTS Reading test is tough and they have a very short amount of time to answer a large number of questions on very complicated texts.